4f4w
From Proteopedia
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| - | [[Image:4f4w.png|left|200px]] | ||
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{{STRUCTURE_4f4w| PDB=4f4w | SCENE= }} | {{STRUCTURE_4f4w| PDB=4f4w | SCENE= }} | ||
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===Y-family DNA polymerase chimera Dbh-Dpo4-Dpo4 #1=== | ===Y-family DNA polymerase chimera Dbh-Dpo4-Dpo4 #1=== | ||
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{{ABSTRACT_PUBMED_23245850}} | {{ABSTRACT_PUBMED_23245850}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DPO4_SULAC DPO4_SULAC]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4f4w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4W OCA]. | + | [[4f4w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulac Sulac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4W OCA]. |
==See Also== | ==See Also== | ||
*[[DNA polymerase|DNA polymerase]] | *[[DNA polymerase|DNA polymerase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023245850</ref><references group="xtra"/><references/> | ||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
| + | [[Category: Sulac]] | ||
[[Category: Pata, J D.]] | [[Category: Pata, J D.]] | ||
[[Category: Wilson, R C.]] | [[Category: Wilson, R C.]] | ||
[[Category: Transferase-dna complex]] | [[Category: Transferase-dna complex]] | ||
[[Category: Y-family polymerase]] | [[Category: Y-family polymerase]] | ||
Revision as of 06:01, 29 January 2014
Contents |
Y-family DNA polymerase chimera Dbh-Dpo4-Dpo4 #1
Template:ABSTRACT PUBMED 23245850
Function
[DPO4_SULAC] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis (By similarity).
About this Structure
4f4w is a 6 chain structure with sequence from Sulac. Full crystallographic information is available from OCA.
See Also
Reference
- Wilson RC, Jackson MA, Pata JD. Y-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion Specificity. Structure. 2012 Dec 11. pii: S0969-2126(12)00420-0. doi:, 10.1016/j.str.2012.11.005. PMID:23245850 doi:http://dx.doi.org/10.1016/j.str.2012.11.005
