4c3d

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{{STRUCTURE_4c3d| PDB=4c3d | SCENE= }}
{{STRUCTURE_4c3d| PDB=4c3d | SCENE= }}
===HRSV M2-1, P422 crystal form===
===HRSV M2-1, P422 crystal form===
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{{ABSTRACT_PUBMED_24434552}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024434552</ref><references group="xtra"/><references/>
[[Category: Ariza, A.]]
[[Category: Ariza, A.]]
[[Category: Barr, J N.]]
[[Category: Barr, J N.]]

Revision as of 06:04, 29 January 2014

Template:STRUCTURE 4c3d

Contents

HRSV M2-1, P422 crystal form

Template:ABSTRACT PUBMED 24434552

Function

[M21_HRSVA] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.[1] [2] [3]

About this Structure

4c3d is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincao J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eleouet JF, Edwards TA, Barr JN. Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A. 2014 Jan 16. PMID:24434552 doi:http://dx.doi.org/10.1073/pnas.1317262111
  1. ↑ Collins PL, Hill MG, Cristina J, Grosfeld H. Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):81-5. PMID:8552680
  2. ↑ Hardy RW, Wertz GW. The product of the respiratory syncytial virus M2 gene ORF1 enhances readthrough of intergenic junctions during viral transcription. J Virol. 1998 Jan;72(1):520-6. PMID:9420254
  3. ↑ Fearns R, Collins PL. Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription. J Virol. 1999 Jul;73(7):5852-64. PMID:10364337

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