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4lzr

From Proteopedia

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{{STRUCTURE_4lzr| PDB=4lzr | SCENE= }}
{{STRUCTURE_4lzr| PDB=4lzr | SCENE= }}
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===Crystal Structure of BRD4(1) bound to inhibitor XD25===
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===Crystal Structure of BRD4(1) bound to Colchicine===
{{ABSTRACT_PUBMED_24272870}}
{{ABSTRACT_PUBMED_24272870}}

Revision as of 06:29, 29 January 2014

Template:STRUCTURE 4lzr

Contents

Crystal Structure of BRD4(1) bound to Colchicine

Template:ABSTRACT PUBMED 24272870

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4lzr is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Lucas X, Wohlwend D, Hugle M, Schmidtkunz K, Gerhardt S, Schule R, Jung M, Einsle O, Gunther S. 4-acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. doi: 10.1002/anie.201307652. , Epub 2013 Nov 24. PMID:24272870 doi:http://dx.doi.org/10.1002/anie.201307652
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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