4keh
From Proteopedia
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{{STRUCTURE_4keh| PDB=4keh | SCENE= }} | {{STRUCTURE_4keh| PDB=4keh | SCENE= }} | ||
===Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP=== | ===Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP=== | ||
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==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024362570</ref><references group="xtra"/><references/> |
[[Category: Burkart, M.]] | [[Category: Burkart, M.]] | ||
[[Category: Finzel, K.]] | [[Category: Finzel, K.]] | ||
Revision as of 06:30, 29 January 2014
Contents |
Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP
Template:ABSTRACT PUBMED 24362570
Function
[FABA_ECOLI] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. Is inactive in the dehydration of long chain unsaturated beta-hydroxyacyl-ACP.[1] [K0BL73_ECO1E] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[RuleBase:RU003545][HAMAP-Rule:MF_01217]
About this Structure
4keh is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Nguyen C, Haushalter RW, Lee DJ, Markwick PR, Bruegger J, Caldara-Festin G, Finzel K, Jackson DR, Ishikawa F, O'Dowd B, McCammon JA, Opella SJ, Tsai SC, Burkart MD. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 2014 Jan 16;505(7483):427-31. doi: 10.1038/nature12810. Epub 2013 Dec 22. PMID:24362570 doi:http://dx.doi.org/10.1038/nature12810
