3d8y

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[[Image:3d8y.png|left|200px]]
 
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{{STRUCTURE_3d8y| PDB=3d8y | SCENE= }}
{{STRUCTURE_3d8y| PDB=3d8y | SCENE= }}
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===RNase A- 5'-Deoxy-5'-N-piperidinothymidine complex===
===RNase A- 5'-Deoxy-5'-N-piperidinothymidine complex===
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{{ABSTRACT_PUBMED_19173562}}
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{{ABSTRACT_PUBMED_19173562}}
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==Function==
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[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019173562</ref><references group="xtra"/>
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<ref group="xtra">PMID:019173562</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Pancreatic ribonuclease]]

Revision as of 06:31, 29 January 2014

Template:STRUCTURE 3d8y

Contents

RNase A- 5'-Deoxy-5'-N-piperidinothymidine complex

Template:ABSTRACT PUBMED 19173562

Function

[RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.[1]

About this Structure

3d8y is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

See Also

Reference

  • Samanta A, Leonidas DD, Dasgupta S, Pathak T, Zographos SE, Oikonomakos NG. Morpholino, Piperidino, and Pyrrolidino Derivatives of Pyrimidine Nucleosides as Inhibitors of Ribonuclease A: Synthesis, Biochemical, and Crystallographic Evaluation (#) (,) (dagger). J Med Chem. 2009 Jan 27. PMID:19173562 doi:10.1021/jm800724t
  1. delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688

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