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4lry

From Proteopedia

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m (Protected "4lry" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lry| PDB=4lry | SCENE= }}
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===Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex===
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{{ABSTRACT_PUBMED_24440518}}
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The entry 4lry is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/DHAK_ECOLI DHAK_ECOLI]] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [[http://www.uniprot.org/uniprot/DHAR_ECOLI DHAR_ECOLI]] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis.
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Authors: Shi, R., McDonald, L., Cygler, M., Ekiel, I.
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==About this Structure==
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[[4lry]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRY OCA].
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Description: Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex
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==Reference==
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<ref group="xtra">PMID:024440518</ref><references group="xtra"/><references/>
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[[Category: Cygler, M.]]
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[[Category: Ekiel, I.]]
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[[Category: McDonald, L.]]
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[[Category: Shi, R.]]
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[[Category: Coiled-coil]]
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[[Category: Gaf]]
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[[Category: Helix rotation]]
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[[Category: Pa]]
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[[Category: Transcriptional regulation complex]]
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[[Category: Transferase-transcription regulator complex]]

Revision as of 07:35, 29 January 2014

Template:STRUCTURE 4lry

Contents

Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex

Template:ABSTRACT PUBMED 24440518

Function

[DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [DHAR_ECOLI] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis.

About this Structure

4lry is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Shi R, McDonald L, Cygler M, Ekiel I. Coiled-Coil Helix Rotation Selects Repressing or Activating State of Transcriptional Regulator DhaR. Structure. 2014 Jan 14. pii: S0969-2126(13)00471-1. doi:, 10.1016/j.str.2013.11.012. PMID:24440518 doi:http://dx.doi.org/10.1016/j.str.2013.11.012

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OCA

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