2m45

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'''Unreleased structure'''
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{{STRUCTURE_2m45| PDB=2m45 | SCENE= }}
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===NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus===
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The entry 2m45 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
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Authors: Wiedemann, C., Ohlenschlager, O., Medagli, B., Onesti, S., Gorlach, M.
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==About this Structure==
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[[2m45]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M45 OCA].
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Description: NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus
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==Reference==
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<references group="xtra"/><references/>
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[[Category: DNA helicase]]
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[[Category: Gorlach, M.]]
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[[Category: Medagli, B.]]
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[[Category: Ohlenschlager, O.]]
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[[Category: Onesti, S.]]
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[[Category: Wiedemann, C.]]
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[[Category: Dna helicase]]
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[[Category: Helix-turn-helix]]
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[[Category: Hydrolase]]
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[[Category: Mcm]]
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[[Category: Minichromosome maintenance protein]]
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[[Category: Pre-replicative complex]]
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[[Category: Replication]]
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[[Category: Thermophile protein]]
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[[Category: Winged helix]]
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[[Category: Winged helix turn]]

Revision as of 07:41, 29 January 2014

Template:STRUCTURE 2m45

Contents

NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus

Function

[MCM_SULSO] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.[1]

About this Structure

2m45 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM. Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus. J Biol Chem. 2002 Apr 5;277(14):12118-27. Epub 2002 Jan 30. PMID:11821426 doi:10.1074/jbc.M200091200

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