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2miq

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_2miq| PDB=2miq | SCENE= }}
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===Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J===
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The entry 2miq is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME]] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref>
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Authors: Xu, X., Elestky, A., Shastry, R., Maglaqui, M., Janjua, H., Xiao, R., Everett, J.K., Sukumaran, D.K., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
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==About this Structure==
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[[2miq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIQ OCA].
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Description: Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Elestky, A.]]
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[[Category: Everett, J K.]]
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[[Category: Janjua, H.]]
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[[Category: Maglaqui, M.]]
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[[Category: Montelione, G T.]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Shastry, R.]]
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[[Category: Sukumaran, D K.]]
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[[Category: Szyperski, T.]]
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[[Category: Xiao, R.]]
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[[Category: Xu, X.]]
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[[Category: Oxidoreductase]]
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[[Category: Zinc finger]]

Revision as of 07:42, 29 January 2014

Template:STRUCTURE 2miq

Contents

Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J

Function

[KDM5_DROME] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.[1] [2] [3] [4]

About this Structure

2miq is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Gildea JJ, Lopez R, Shearn A. A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics. 2000 Oct;156(2):645-63. PMID:11014813
  2. ↑ Secombe J, Li L, Carlos L, Eisenman RN. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 2007 Mar 1;21(5):537-51. Epub 2007 Feb 20. PMID:17311883 doi:http://dx.doi.org/10.1101/gad.1523007
  3. ↑ Lee N, Zhang J, Klose RJ, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol. 2007 Apr;14(4):341-3. Epub 2007 Mar 11. PMID:17351631 doi:http://dx.doi.org/10.1038/nsmb1216
  4. ↑ Eissenberg JC, Lee MG, Schneider J, Ilvarsonn A, Shiekhattar R, Shilatifard A. The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol. 2007 Apr;14(4):344-6. Epub 2007 Mar 11. PMID:17351630 doi:http://dx.doi.org/10.1038/nsmb1217

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