3wkt

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'''Unreleased structure'''
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{{STRUCTURE_3wkt| PDB=3wkt | SCENE= }}
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===Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1===
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The entry 3wkt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NCPR_RAT NCPR_RAT]] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. [[http://www.uniprot.org/uniprot/HMOX1_RAT HMOX1_RAT]] Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
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Authors: Sugishima, M., Sato, H., Higashimoto, Y., Harada, J., Wada, K., Fukuyama, K., Noguchi, M.
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==About this Structure==
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[[3wkt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WKT OCA].
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Description: Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1
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[[Category: NADPH--hemoprotein reductase]]
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[[Category: Fukuyama, K.]]
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[[Category: Harada, J.]]
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[[Category: Higashimoto, Y.]]
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[[Category: Noguchi, M.]]
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[[Category: Sato, H.]]
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[[Category: Sugishima, M.]]
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[[Category: Wada, K.]]
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[[Category: Heme degradation]]
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[[Category: Microsomal membrane]]
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[[Category: Oxidoreductase]]

Revision as of 07:43, 29 January 2014

Template:STRUCTURE 3wkt

Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1

Function

[NCPR_RAT] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. [HMOX1_RAT] Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.

About this Structure

3wkt is a 4 chain structure. Full crystallographic information is available from OCA.

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OCA

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