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4cko
From Proteopedia
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| - | + | {{STRUCTURE_4cko| PDB=4cko | SCENE= }} | |
| + | ===Crystal structure of the neuronal isoform of PTB=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/PTBP2_HUMAN PTBP2_HUMAN]] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.<ref>PMID:11003644</ref> <ref>PMID:12667457</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4cko]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKO OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Buckroyd, A N.]] | ||
| + | [[Category: Curry, S.]] | ||
| + | [[Category: Joshi, A.]] | ||
| + | [[Category: Brptb]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Translation]] | ||
Revision as of 07:44, 29 January 2014
Contents |
Crystal structure of the neuronal isoform of PTB
Function
[PTBP2_HUMAN] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.[1] [2]
About this Structure
4cko is a 8 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol. 2000 Oct;20(20):7463-79. PMID:11003644
- ↑ Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell. 2003 Mar;11(3):757-71. PMID:12667457
