4lld
From Proteopedia
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| - | + | {{STRUCTURE_4lld| PDB=4lld | SCENE= }} | |
| + | ===Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A=== | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | ||
| - | + | ==About this Structure== | |
| - | + | [[4lld]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLD OCA]. | |
| - | + | [[Category: Atwell, S.]] | |
| + | [[Category: Chamberlain, A K.]] | ||
| + | [[Category: Demarest, S J.]] | ||
| + | [[Category: Guntas, G.]] | ||
| + | [[Category: Hansen-Estruch, C.]] | ||
| + | [[Category: Ho, C.]] | ||
| + | [[Category: Huang, F.]] | ||
| + | [[Category: Kuhlman, B.]] | ||
| + | [[Category: Leaver-Fay, A.]] | ||
| + | [[Category: Lewis, S M.]] | ||
| + | [[Category: Pustilnik, A.]] | ||
| + | [[Category: Sereno, A.]] | ||
| + | [[Category: Smith, E M.]] | ||
| + | [[Category: Truhlar, S M.]] | ||
| + | [[Category: Wu, X.]] | ||
| + | [[Category: Fragment of antibody]] | ||
| + | [[Category: Igg domain]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 07:48, 29 January 2014
Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A
Disease
[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
About this Structure
4lld is a 2 chain structure. Full crystallographic information is available from OCA.
