4mmh

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m (Protected "4mmh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4mmh| PDB=4mmh | SCENE= }}
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===Crystal structure of heparan sulfate lyase HepC from Pedobacter heparinus===
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The entry 4mmh is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HEPC_PEDHD HEPC_PEDHD]] Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.<ref>PMID:8702264</ref> <ref>PMID:10747789</ref>
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Authors: Maruyama, Y., Nakamichi, Y., Mikami, B., Murata, K., Hashimoto, W.
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==About this Structure==
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[[4mmh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MMH OCA].
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Description: Crystal structure of heparan sulfate lyase HepC from Pedobacter heparinus
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Heparin-sulfate lyase]]
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[[Category: Hashimoto, W.]]
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[[Category: Maruyama, Y.]]
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[[Category: Mikami, B.]]
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[[Category: Murata, K.]]
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[[Category: Nakamichi, Y.]]
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[[Category: Alpha/alpha barrel anti-parallel beta-sheet]]
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[[Category: Heparinase]]
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[[Category: Lyase]]

Revision as of 07:50, 29 January 2014

Template:STRUCTURE 4mmh

Contents

Crystal structure of heparan sulfate lyase HepC from Pedobacter heparinus

Function

[HEPC_PEDHD] Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.[1] [2]

About this Structure

4mmh is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Su H, Blain F, Musil RA, Zimmermann JJ, Gu K, Bennett DC. Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum. Appl Environ Microbiol. 1996 Aug;62(8):2723-34. PMID:8702264
  2. ↑ Pojasek K, Shriver Z, Hu Y, Sasisekharan R. Histidine 295 and histidine 510 are crucial for the enzymatic degradation of heparan sulfate by heparinase III. Biochemistry. 2000 Apr 11;39(14):4012-9. PMID:10747789

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