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4mi8

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'''Unreleased structure'''
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{{STRUCTURE_4mi8| PDB=4mi8 | SCENE= }}
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===Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide===
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The entry 4mi8 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
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Authors: Su, M., Mei, Y.
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==About this Structure==
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[[4mi8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MI8 OCA].
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Description: Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mei, Y.]]
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[[Category: Su, M.]]
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[[Category: Anti-apoptotic and anti-autophagic activity]]
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[[Category: Bcl-2 family]]
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[[Category: Bh3d]]
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[[Category: Viral protein-apoptosis complex]]

Revision as of 07:50, 29 January 2014

Template:STRUCTURE 4mi8

Contents

Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide

Function

[BECN1_HUMAN] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.[1]

About this Structure

4mi8 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Sagona AP, Nezis IP, Pedersen NM, Liestol K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol. 2010 Apr;12(4):362-71. doi: 10.1038/ncb2036. Epub 2010 Mar 7. PMID:20208530 doi:http://dx.doi.org/10.1038/ncb2036

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