4n9z

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'''Unreleased structure'''
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{{STRUCTURE_4n9z| PDB=4n9z | SCENE= }}
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===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q===
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The entry 4n9z is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
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Authors: Wang, Z., Cheng, Z., Xu, W.
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==About this Structure==
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[[4n9z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA].
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Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q
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[[Category: Cheng, Z.]]
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[[Category: Wang, Z.]]
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[[Category: Xu, W.]]
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[[Category: Hydrolase]]
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[[Category: Parg]]

Revision as of 07:50, 29 January 2014

Template:STRUCTURE 4n9z

Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q

Function

[PARG_MOUSE] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).

About this Structure

4n9z is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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