4na0
From Proteopedia
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| - | + | {{STRUCTURE_4na0| PDB=4na0 | SCENE= }} | |
| + | ===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADPRibose=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[4na0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA0 OCA]. | |
| - | + | [[Category: Cheng, Z.]] | |
| + | [[Category: Wang, Z.]] | ||
| + | [[Category: Xu, W.]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 07:50, 29 January 2014
Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADPRibose
Function
[PARG_MOUSE] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
About this Structure
4na0 is a 3 chain structure. Full crystallographic information is available from OCA.
Categories: Cheng, Z. | Wang, Z. | Xu, W. | Hydrolase
