3b8z
From Proteopedia
(New page: 200px<br /><applet load="3b8z" size="350" color="white" frame="true" align="right" spinBox="true" caption="3b8z, resolution 1.400Å" /> '''High Resolution Cry...) |
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==Overview== | ==Overview== | ||
| - | Aggrecanase-2 | + | Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis. |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2007 Nov 8 | + | High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17991750 17991750] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Mathis, K | + | [[Category: Mathis, K J.]] |
| - | [[Category: Shieh, H | + | [[Category: Shieh, H S.]] |
[[Category: Tomasselli, A.]] | [[Category: Tomasselli, A.]] | ||
| - | [[Category: Tortorella, M | + | [[Category: Tortorella, M D.]] |
| - | [[Category: Williams, J | + | [[Category: Williams, J M.]] |
[[Category: 294]] | [[Category: 294]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:18 2008'' |
Revision as of 17:04, 21 February 2008
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High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
Overview
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
About this Structure
3B8Z is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:17991750
Page seeded by OCA on Thu Feb 21 19:04:18 2008
Categories: Homo sapiens | Single protein | Mathis, K J. | Shieh, H S. | Tomasselli, A. | Tortorella, M D. | Williams, J M. | 294 | CA | ZN | Alpha/beta | Hydrolase
