4c2i
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[4c2i]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4c2i]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2I OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024421336</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024421336</ref><references group="xtra"/><references/> | ||
| - | [[Category: Dengue virus | + | [[Category: Dengue virus 1]] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Alwis, R de.]] | [[Category: Alwis, R de.]] | ||
Revision as of 07:33, 5 February 2014
Contents |
Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4
Template:ABSTRACT PUBMED 24421336
Function
[Q7TGE4_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] [G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
About this Structure
4c2i is a 10 chain structure with sequence from Dengue virus 1 and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Fibriansah G, Tan JL, Smith SA, de Alwis AR, Ng TS, Kostyuchenko VA, Ibarra KD, Wang J, Harris E, de Silva A, Crowe JE Jr, Lok SM. A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface. EMBO Mol Med. 2014 Jan 13. PMID:24421336 doi:http://dx.doi.org/10.1002/emmm.201303404
