2xfh
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2xfh| PDB=2xfh | SCENE= }} | {{STRUCTURE_2xfh| PDB=2xfh | SCENE= }} | ||
| - | === | + | ===Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.=== |
{{ABSTRACT_PUBMED_20845962}} | {{ABSTRACT_PUBMED_20845962}} | ||
| - | |||
| - | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/CPXQ_SACEN CPXQ_SACEN]] Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.<ref>PMID:8416893</ref> <ref>PMID:7849045</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/> | ||
| - | [[Category: Saccharopolyspora erythraea]] | ||
[[Category: Gianni, S.]] | [[Category: Gianni, S.]] | ||
[[Category: Montemiglio, L C.]] | [[Category: Montemiglio, L C.]] | ||
Revision as of 08:04, 5 February 2014
Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.
Template:ABSTRACT PUBMED 20845962
About this Structure
2xfh is a 1 chain structure with sequence from "actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923. This structure supersedes the now removed PDB entry 2vrv. Full crystallographic information is available from OCA.
Reference
- Montemiglio LC, Gianni S, Vallone B, Savino C. Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry. 2010 Sep 16. PMID:20845962 doi:10.1021/bi101062v
