This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2xfh
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_2xfh| PDB=2xfh | SCENE= }} | {{STRUCTURE_2xfh| PDB=2xfh | SCENE= }} | ||
| - | === | + | ===Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.=== |
{{ABSTRACT_PUBMED_20845962}} | {{ABSTRACT_PUBMED_20845962}} | ||
| - | |||
| - | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/CPXQ_SACEN CPXQ_SACEN]] Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.<ref>PMID:8416893</ref> <ref>PMID:7849045</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/> | ||
| - | [[Category: Saccharopolyspora erythraea]] | ||
[[Category: Gianni, S.]] | [[Category: Gianni, S.]] | ||
[[Category: Montemiglio, L C.]] | [[Category: Montemiglio, L C.]] | ||
Revision as of 08:04, 5 February 2014
Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.
Template:ABSTRACT PUBMED 20845962
About this Structure
2xfh is a 1 chain structure with sequence from "actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923. This structure supersedes the now removed PDB entry 2vrv. Full crystallographic information is available from OCA.
Reference
- Montemiglio LC, Gianni S, Vallone B, Savino C. Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry. 2010 Sep 16. PMID:20845962 doi:10.1021/bi101062v
