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3g2w

From Proteopedia

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[[Image:3g2w.png|left|200px]]
 
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{{STRUCTURE_3g2w| PDB=3g2w | SCENE= }}
{{STRUCTURE_3g2w| PDB=3g2w | SCENE= }}
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===VHS Domain of human GGA1 complexed with a DXXLL hinge peptide===
===VHS Domain of human GGA1 complexed with a DXXLL hinge peptide===
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{{ABSTRACT_PUBMED_20015111}}
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==Function==
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[[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref>
==About this Structure==
==About this Structure==
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[[3g2w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2W OCA].
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[[3g2w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2W OCA].
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[[Category: Homo sapiens]]
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==Reference==
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<ref group="xtra">PMID:020015111</ref><references group="xtra"/><references/>
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[[Category: Human]]
[[Category: Behrens, M A.]]
[[Category: Behrens, M A.]]
[[Category: Cramer, J F.]]
[[Category: Cramer, J F.]]

Revision as of 08:22, 5 February 2014

Template:STRUCTURE 3g2w

Contents

VHS Domain of human GGA1 complexed with a DXXLL hinge peptide

Template:ABSTRACT PUBMED 20015111

Function

[GGA1_HUMAN] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.[1]

About this Structure

3g2w is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Cramer JF, Gustafsen C, Behrens MA, Oliveira CL, Pedersen JS, Madsen P, Petersen CM, Thirup SS. GGA Autoinhibition Revisited. Traffic. 2010 Feb;11(2):259-73. Epub 2009 Nov 10. PMID:20015111 doi:http://dx.doi.org/TRA1017
  1. ↑ Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS. The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell. 2001 Apr 6;105(1):93-102. PMID:11301005

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