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3bct

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(New page: 200px<br /><applet load="3bct" size="450" color="white" frame="true" align="right" spinBox="true" caption="3bct, resolution 2.10&Aring;" /> '''THE ARMADILLO REPEAT...)
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[[Image:3bct.gif|left|200px]]<br /><applet load="3bct" size="350" color="white" frame="true" align="right" spinBox="true"
caption="3bct, resolution 2.10&Aring;" />
caption="3bct, resolution 2.10&Aring;" />
'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''<br />
'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''<br />
==Overview==
==Overview==
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Beta-catenin is essential for cadherin-based cell adhesion and, Wnt/Wingless growth factor signaling. In these roles, it binds to, cadherins, Tcf-family transcription factors, and the tumor suppressor gene, product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an, armadillo repeat, mediates these interactions. The three-dimensional, structure of a protease-resistant fragment of beta-catenin containing the, armadillo repeat region has been determined. The 12 repeats form a, superhelix of helices that features a long, positively charged groove., Although unrelated in sequence, the beta-catenin binding regions of, cadherins, Tcfs, and APC are acidic and are proposed to interact with this, groove.
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Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.
==About this Structure==
==About this Structure==
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3BCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CL and URE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3BCT OCA].
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3BCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=URE:'>URE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCT OCA].
==Reference==
==Reference==
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Huber, A.H.]]
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[[Category: Huber, A H.]]
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[[Category: Nelson, W.J.]]
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[[Category: Nelson, W J.]]
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[[Category: Weis, W.I.]]
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[[Category: Weis, W I.]]
[[Category: CL]]
[[Category: CL]]
[[Category: URE]]
[[Category: URE]]
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[[Category: cytoskeleton]]
[[Category: cytoskeleton]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:26:45 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:54 2008''

Revision as of 17:04, 21 February 2008

Image:3bct.gif

3bct, resolution 2.10Å

Drag the structure with the mouse to rotate

THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

Overview

Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.

About this Structure

3BCT is a Single protein structure of sequence from Mus musculus with and as ligands. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899

Page seeded by OCA on Thu Feb 21 19:04:54 2008

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