3g2t
From Proteopedia
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{{STRUCTURE_3g2t| PDB=3g2t | SCENE= }} | {{STRUCTURE_3g2t| PDB=3g2t | SCENE= }} | ||
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===VHS Domain of human GGA1 complexed with SorLA C-terminal Phosphopeptide=== | ===VHS Domain of human GGA1 complexed with SorLA C-terminal Phosphopeptide=== | ||
| + | {{ABSTRACT_PUBMED_20015111}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3g2t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3g2t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2T OCA]. |
| - | [[Category: | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020015111</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Behrens, M A.]] | [[Category: Behrens, M A.]] | ||
[[Category: Cramer, J F.]] | [[Category: Cramer, J F.]] | ||
Revision as of 08:45, 5 February 2014
Contents |
VHS Domain of human GGA1 complexed with SorLA C-terminal Phosphopeptide
Template:ABSTRACT PUBMED 20015111
Function
[GGA1_HUMAN] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.[1] [SORL_HUMAN] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
About this Structure
3g2t is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Cramer JF, Gustafsen C, Behrens MA, Oliveira CL, Pedersen JS, Madsen P, Petersen CM, Thirup SS. GGA Autoinhibition Revisited. Traffic. 2010 Feb;11(2):259-73. Epub 2009 Nov 10. PMID:20015111 doi:http://dx.doi.org/TRA1017
