3cf6

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[[Image:3cf6.png|left|200px]]
 
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{{STRUCTURE_3cf6| PDB=3cf6 | SCENE= }}
{{STRUCTURE_3cf6| PDB=3cf6 | SCENE= }}
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===Structure of Epac2 in complex with cyclic-AMP and Rap===
===Structure of Epac2 in complex with cyclic-AMP and Rap===
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{{ABSTRACT_PUBMED_18660803}}
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{{ABSTRACT_PUBMED_18660803}}
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==Function==
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[[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref>
==About this Structure==
==About this Structure==
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[[3cf6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CF6 OCA].
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[[3cf6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CF6 OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018660803</ref><ref group="xtra">PMID:016452984</ref><ref group="xtra">PMID:012469113</ref><references group="xtra"/>
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<ref group="xtra">PMID:018660803</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
[[Category: Arias-Palomo, E.]]
[[Category: Arias-Palomo, E.]]
[[Category: Bos, J L.]]
[[Category: Bos, J L.]]

Revision as of 08:54, 5 February 2014

Template:STRUCTURE 3cf6

Contents

Structure of Epac2 in complex with cyclic-AMP and Rap

Template:ABSTRACT PUBMED 18660803

Function

[RAP1B_HUMAN] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.[1] [2]

About this Structure

3cf6 is a 2 chain structure with sequence from Human and Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

Reference

  • Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7. Epub 2008 Jul 27. PMID:18660803 doi:http://dx.doi.org/10.1038/nature07187
  1. ↑ Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. doi: 10.1242/jcs.059329. PMID:20332120 doi:10.1242/jcs.059329
  2. ↑ Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7. Epub 2008 Jul 27. PMID:18660803 doi:http://dx.doi.org/10.1038/nature07187

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