4lcu

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{{STRUCTURE_4lcu| PDB=4lcu | SCENE= }}
{{STRUCTURE_4lcu| PDB=4lcu | SCENE= }}
===Structure of KcsA with E118A mutation===
===Structure of KcsA with E118A mutation===
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{{ABSTRACT_PUBMED_24218397}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4lcu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCU OCA].
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[[4lcu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCU OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
+
<ref group="xtra">PMID:024218397</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
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[[Category: Streptomyces lividans]]
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[[Category: Lk3 transgenic mice]]
[[Category: McCoy, J M.]]
[[Category: McCoy, J M.]]
[[Category: Nimigean, C M.]]
[[Category: Nimigean, C M.]]

Revision as of 09:29, 5 February 2014

Template:STRUCTURE 4lcu

Contents

Structure of KcsA with E118A mutation

Template:ABSTRACT PUBMED 24218397

Function

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]

About this Structure

4lcu is a 3 chain structure with sequence from "actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965 and Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  • Posson DJ, Thompson AN, McCoy JG, Nimigean CM. Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J Gen Physiol. 2013 Dec;142(6):613-24. doi: 10.1085/jgp.201311057. Epub 2013 Nov , 11. PMID:24218397 doi:http://dx.doi.org/10.1085/jgp.201311057
  1. ↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

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