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2yne

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{{STRUCTURE_2yne| PDB=2yne | SCENE= }}
{{STRUCTURE_2yne| PDB=2yne | SCENE= }}
===Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor===
===Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor===
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{{ABSTRACT_PUBMED_24451586}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
[[2yne]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNE OCA].
[[2yne]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNE OCA].
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==Reference==
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<ref group="xtra">PMID:024451586</ref><references group="xtra"/><references/>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Bottrill, A R.]]
[[Category: Bottrill, A R.]]

Revision as of 09:32, 5 February 2014

Template:STRUCTURE 2yne

Contents

Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor

Template:ABSTRACT PUBMED 24451586

Function

[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]

About this Structure

2yne is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. PMID:24451586 doi:http://dx.doi.org/10.1038/nchem.1830

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