4cge

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4cge" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4cge| PDB=4cge | SCENE= }}
 +
===Bacterial secreted hydrolase A===
 +
{{ABSTRACT_PUBMED_24452911}}
-
The entry 4cge is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/RPFE_MYCTU RPFE_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref>
-
Authors: Mavrici, D., Prigozhin, D.M., Alber, T.
+
==About this Structure==
 +
[[4cge]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGE OCA].
-
Description: Bacterial secreted hydrolase A
+
==Reference==
 +
<ref group="xtra">PMID:024452911</ref><references group="xtra"/><references/>
 +
[[Category: Alber, T.]]
 +
[[Category: Mavrici, D.]]
 +
[[Category: Prigozhin, D M.]]
 +
[[Category: Hydrolase]]
 +
[[Category: Secreted protein]]

Revision as of 11:07, 5 February 2014

Template:STRUCTURE 4cge

Contents

Bacterial secreted hydrolase A

Template:ABSTRACT PUBMED 24452911

Function

[RPFE_MYCTU] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.[1] Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.[2]

About this Structure

4cge is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mavrici D, Prigozhin DM, Alber T. Mycobacterium tuberculosis RpfE crystal structure reveals a positively charged catalytic cleft. Protein Sci. 2014 Jan 22. doi: 10.1002/pro.2431. PMID:24452911 doi:http://dx.doi.org/10.1002/pro.2431
  1. ↑ Mukamolova GV, Turapov OA, Young DI, Kaprelyants AS, Kell DB, Young M. A family of autocrine growth factors in Mycobacterium tuberculosis. Mol Microbiol. 2002 Nov;46(3):623-35. PMID:12410821
  2. ↑ Mukamolova GV, Turapov OA, Young DI, Kaprelyants AS, Kell DB, Young M. A family of autocrine growth factors in Mycobacterium tuberculosis. Mol Microbiol. 2002 Nov;46(3):623-35. PMID:12410821

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cge"
Personal tools