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2mh3

From Proteopedia

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m (Protected "2mh3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2mh3| PDB=2mh3 | SCENE= }}
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===NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1===
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{{ABSTRACT_PUBMED_24403087}}
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The entry 2mh3 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN]] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>
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Authors: Wienk, H., Popovic, M., Coglievina, M., Boelens, R., Pongor, S., Pintar, A.
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==About this Structure==
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[[2mh3]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA].
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Description: NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1
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==Reference==
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<ref group="xtra">PMID:024403087</ref><references group="xtra"/><references/>
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[[Category: Boelens, R.]]
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[[Category: Coglievina, M.]]
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[[Category: Pintar, A.]]
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[[Category: Pongor, S.]]
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[[Category: Popovic, M.]]
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[[Category: Wienk, H.]]
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[[Category: Bhlh]]
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[[Category: Dna binding protein]]

Revision as of 11:11, 5 February 2014

Template:STRUCTURE 2mh3

Contents

NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1

Template:ABSTRACT PUBMED 24403087

Function

[HES1_HUMAN] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.[1]

About this Structure

2mh3 is a 2 chain structure. Full experimental information is available from OCA.

Reference

  • Popovic M, Wienk H, Coglievina M, Boelens R, Pongor S, Pintar A. The basic-helix-loop-helix region of the transcriptional repressor HES-1 is preorganized to bind DNA. Proteins. 2014 Jan 8. doi: 10.1002/prot.24507. PMID:24403087 doi:http://dx.doi.org/10.1002/prot.24507
  1. ↑ Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Levesque G, Carreau M. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008 Sep 1;112(5):2062-70. doi: 10.1182/blood-2008-04-152710. Epub 2008, Jun 11. PMID:18550849 doi:http://dx.doi.org/10.1182/blood-2008-04-152710

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