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4j2r

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4j2r| PDB=4j2r | SCENE= }}
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===Middle domain of influenza A virus RNA-dependent polymerase PB2===
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{{ABSTRACT_PUBMED_24419622}}
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The entry 4j2r is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
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Authors: Qiu, H., Tsurumura, T., Tsumori, Y., Hatakeyama, D., Kuzuhara, T., Tsuge, H.
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==About this Structure==
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[[4j2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2R OCA].
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Description: Middle domain of influenza A virus RNA-dependent polymerase PB2
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==Reference==
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<ref group="xtra">PMID:024419622</ref><references group="xtra"/><references/>
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[[Category: Hatakeyama, D.]]
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[[Category: Kuzuhara, T.]]
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[[Category: Qiu, H.]]
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[[Category: Tsuge, H.]]
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[[Category: Tsumori, Y.]]
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[[Category: Tsurumura, T.]]
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[[Category: Cap-binding domain]]
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[[Category: Cap-snatching]]
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[[Category: Viral protein]]

Revision as of 11:18, 5 February 2014

Template:STRUCTURE 4j2r

Contents

Middle domain of influenza A virus RNA-dependent polymerase PB2

Template:ABSTRACT PUBMED 24419622

Function

[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).

About this Structure

4j2r is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Tsurumura T, Qiu H, Yoshida T, Tsumori Y, Tsuge H. Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus. Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):72-5. doi:, 10.1107/S2053230X13032603. Epub 2013 Dec 24. PMID:24419622 doi:http://dx.doi.org/10.1107/S2053230X13032603

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OCA

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