4nbo

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'''Unreleased structure'''
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{{STRUCTURE_4nbo| PDB=4nbo | SCENE= }}
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===Human steroid receptor RNA activator protein carboxy-terminal domain===
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The entry 4nbo is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/SRA1_HUMAN SRA1_HUMAN]] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.<ref>PMID:10199399</ref> <ref>PMID:12943696</ref> <ref>PMID:14517287</ref> <ref>PMID:15351741</ref> <ref>PMID:15147866</ref>
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Authors: Mckay, D.B., Xi, L., Barthel, K.K.B., Cech, T.C.
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==About this Structure==
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[[4nbo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NBO OCA].
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Description: Human steroid receptor RNA activator protein carboxy-terminal domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Barthel, K K.B.]]
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[[Category: Cech, T C.]]
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[[Category: Mckay, D B.]]
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[[Category: Xi, L.]]
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[[Category: 5-helix bundle]]
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[[Category: Transcription]]

Revision as of 11:37, 5 February 2014

Template:STRUCTURE 4nbo

Contents

Human steroid receptor RNA activator protein carboxy-terminal domain

Function

[SRA1_HUMAN] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.[1] [2] [3] [4] [5]

About this Structure

4nbo is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999 Apr 2;97(1):17-27. PMID:10199399
  2. ↑ Deblois G, Giguere V. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):123-31. PMID:12943696
  3. ↑ Lanz RB, Chua SS, Barron N, Soder BM, DeMayo F, O'Malley BW. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol. 2003 Oct;23(20):7163-76. PMID:14517287
  4. ↑ Coleman KM, Lam V, Jaber BM, Lanz RB, Smith CL. SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. Biochem Biophys Res Commun. 2004 Oct 8;323(1):332-8. PMID:15351741 doi:http://dx.doi.org/10.1016/j.bbrc.2004.08.090
  5. ↑ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett. 2004 May 21;566(1-3):43-7. PMID:15147866 doi:http://dx.doi.org/10.1016/j.febslet.2004.03.104

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