4o69

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'''Unreleased structure'''
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{{STRUCTURE_4o69| PDB=4o69 | SCENE= }}
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===Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion===
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The entry 4o69 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
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Authors: Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
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==About this Structure==
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[[4o69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O69 OCA].
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Description:
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Cyclic GMP-AMP synthase]]
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[[Category: Chen, Z.]]
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[[Category: Chen, Z J.]]
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[[Category: Zhang, X.]]
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[[Category: Zhang, X W.]]
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[[Category: Immune response]]
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[[Category: Transferase]]

Revision as of 11:38, 5 February 2014

Template:STRUCTURE 4o69

Contents

Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion

Function

[CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.[1] [2]

About this Structure

4o69 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. PMID:21478870 doi:10.1038/nature09907
  2. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458

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OCA

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