Arylamine N-acetyltransferase
From Proteopedia
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[[3d9w]] – NAT – ''Nocardia farcinica''<br /> | [[3d9w]] – NAT – ''Nocardia farcinica''<br /> | ||
[[3lnb]] – NAT (mutant) – ''Bacillus anthracis''<br /> | [[3lnb]] – NAT (mutant) – ''Bacillus anthracis''<br /> | ||
| - | [[2vfb]] - MmNAT – ''Mycobacterium marinum'' | + | [[2vfb]], [[4c5p]] - MmNAT – ''Mycobacterium marinum''<br /> |
| + | [[4bgf]] - NAT – ''Mycobacterium tuberculosis''<br /> | ||
'''Arylamine N-acetyltransferase binary complex''' | '''Arylamine N-acetyltransferase binary complex''' | ||
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[[2vfc]] – MmNAT + CoA<br /> | [[2vfc]] – MmNAT + CoA<br /> | ||
[[3ltw]] – MmNAT + hydralazine<br /> | [[3ltw]] – MmNAT + hydralazine<br /> | ||
| - | [[1w6f]] – MsNAT + anti-tubercular drug | + | [[1w6f]] – MsNAT + anti-tubercular drug<br /> |
| + | [[4b55]] – MmNAT + piperidinol derivative<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:39, 10 February 2014
Arylamine N-acetyltransferase (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine. Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer.
3D structures of arylamine N-acetyltransferase
Updated on 10-February-2014
1gx3 – MsNAT – Mycobacterium smegmatis
1w5r – MsNAT (mutant)
2bsz – NAT1 – Rhizobium loti
2ija – hNAT1 (mutant) – human
2pqt - hNAT1
2pfr – hNAT2
1w4t – NAT – Pseudomonas aeruginosa
3d9w – NAT – Nocardia farcinica
3lnb – NAT (mutant) – Bacillus anthracis
2vfb, 4c5p - MmNAT – Mycobacterium marinum
4bgf - NAT – Mycobacterium tuberculosis
Arylamine N-acetyltransferase binary complex
2vfc – MmNAT + CoA
3ltw – MmNAT + hydralazine
1w6f – MsNAT + anti-tubercular drug
4b55 – MmNAT + piperidinol derivative
