2mcu
From Proteopedia
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{{STRUCTURE_2mcu| PDB=2mcu | SCENE= }} | {{STRUCTURE_2mcu| PDB=2mcu | SCENE= }} | ||
===Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers=== | ===Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers=== | ||
| + | {{ABSTRACT_PUBMED_24410116}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024410116</ref><references group="xtra"/><references/> |
[[Category: Cotten, M L.]] | [[Category: Cotten, M L.]] | ||
[[Category: Fu, R.]] | [[Category: Fu, R.]] | ||
Revision as of 03:30, 13 February 2014
Contents |
Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers
Template:ABSTRACT PUBMED 24410116
Function
[MORO_MORSA] Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores.[1] [2]
About this Structure
2mcu is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Perrin BS Jr, Tian Y, Fu R, Grant CV, Chekmenev EY, Wieczorek WE, Dao AE, Hayden RM, Burzynski CM, Venable RM, Sharma M, Opella SJ, Pastor RW, Cotten ML. High-Resolution Structures and Orientations of Antimicrobial Peptides Piscidin 1 and Piscidin 3 in Fluid Bilayers Reveal Tilting, Kinking, and Bilayer Immersion. J Am Chem Soc. 2014 Jan 22. PMID:24410116 doi:http://dx.doi.org/10.1021/ja411119m
- ↑ Silphaduang U, Noga EJ. Peptide antibiotics in mast cells of fish. Nature. 2001 Nov 15;414(6861):268-9. PMID:11713517 doi:http://dx.doi.org/10.1038/35104690
- ↑ Campagna S, Saint N, Molle G, Aumelas A. Structure and mechanism of action of the antimicrobial peptide piscidin. Biochemistry. 2007 Feb 20;46(7):1771-8. Epub 2007 Jan 25. PMID:17253775 doi:10.1021/bi0620297
