4m11
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4m11| PDB=4m11 | SCENE= }} | {{STRUCTURE_4m11| PDB=4m11 | SCENE= }} | ||
===Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam=== | ===Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam=== | ||
| + | {{ABSTRACT_PUBMED_24425867}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024425867</ref><references group="xtra"/><references/> |
[[Category: Prostaglandin-endoperoxide synthase]] | [[Category: Prostaglandin-endoperoxide synthase]] | ||
[[Category: Banerjee, S.]] | [[Category: Banerjee, S.]] | ||
Revision as of 03:37, 13 February 2014
Contents |
Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Template:ABSTRACT PUBMED 24425867
Function
[PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.[1] [2] [3] [4]
About this Structure
4m11 is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ. Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J Biol Chem. 2014 Jan 14. PMID:24425867 doi:http://dx.doi.org/10.1074/jbc.M113.517987
- ↑ Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ. A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9. Epub 2003 Aug 18. PMID:12925531 doi:http://dx.doi.org/10.1074/jbc.M305481200
- ↑ Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63. Epub 2010 May 12. PMID:20463020 doi:10.1074/jbc.M110.119867
- ↑ Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010 Nov 5;285(45):34950-9. Epub 2010 Sep 1. PMID:20810665 doi:10.1074/jbc.M110.162982
- ↑ Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J Biol Chem. 2011 Jun 10;286(23):20736-45. Epub 2011 Apr 13. PMID:21489986 doi:10.1074/jbc.M111.230367
