4hhd

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{{STRUCTURE_4hhd| PDB=4hhd | SCENE= }}
{{STRUCTURE_4hhd| PDB=4hhd | SCENE= }}
===2.75 Angstrom resolution crystal structure of the A. thaliana LOV2 domain with an extended N-terminal A' helix (cryo dark structure)===
===2.75 Angstrom resolution crystal structure of the A. thaliana LOV2 domain with an extended N-terminal A' helix (cryo dark structure)===
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{{ABSTRACT_PUBMED_24316821}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
+
<ref group="xtra">PMID:024316821</ref><references group="xtra"/><references/>
[[Category: Arath]]
[[Category: Arath]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 04:21, 13 February 2014

Template:STRUCTURE 4hhd

Contents

2.75 Angstrom resolution crystal structure of the A. thaliana LOV2 domain with an extended N-terminal A' helix (cryo dark structure)

Template:ABSTRACT PUBMED 24316821

Function

[PHOT1_ARATH] Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Required for blue light mediated mRNA destabilization. Mediates calcium spiking of extracellular origin in response to a low rate of blue light. Also mediates rapid membrane depolarization and growth inhibition in response to blue light. Necessary for root phototropism. Involved in hypocotyl phototropism under a low rate but not under a high rate of blue light. Contributes to the chloroplast accumulation but seems not to be required for chloroplast translocation. Regulates stomata opening and photomorphogenesis response of leaf tissue. Confers sensitivity to drought. Not involved in hypocotyl elongation inhibition, anthocyanin accumulation or cotyledon opening.[1] [2] [3] [4] [5] [6] [7] [8]

About this Structure

4hhd is a 2 chain structure with sequence from Arath. Full crystallographic information is available from OCA.

Reference

  • Halavaty AS, Moffat K. Coiled-coil dimerization of the LOV2 domain of the blue-light photoreceptor phototropin 1 from Arabidopsis thaliana. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1316-21., doi: 10.1107/S1744309113029199. Epub 2013 Nov 28. PMID:24316821 doi:http://dx.doi.org/10.1107/S1744309113029199
  1. ↑ Sakai T, Wada T, Ishiguro S, Okada K. RPT2. A signal transducer of the phototropic response in Arabidopsis. Plant Cell. 2000 Feb;12(2):225-36. PMID:10662859
  2. ↑ Folta KM, Spalding EP. Unexpected roles for cryptochrome 2 and phototropin revealed by high-resolution analysis of blue light-mediated hypocotyl growth inhibition. Plant J. 2001 Jun;26(5):471-8. PMID:11439133
  3. ↑ Folta KM, Kaufman LS. Phototropin 1 is required for high-fluence blue-light-mediated mRNA destabilization. Plant Mol Biol. 2003 Mar;51(4):609-18. PMID:12650626
  4. ↑ Harada A, Sakai T, Okada K. Phot1 and phot2 mediate blue light-induced transient increases in cytosolic Ca2+ differently in Arabidopsis leaves. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8583-8. Epub 2003 Jun 23. PMID:12821778 doi:http://dx.doi.org/10.1073/pnas.1336802100
  5. ↑ Inada S, Ohgishi M, Mayama T, Okada K, Sakai T. RPT2 is a signal transducer involved in phototropic response and stomatal opening by association with phototropin 1 in Arabidopsis thaliana. Plant Cell. 2004 Apr;16(4):887-96. Epub 2004 Mar 18. PMID:15031408 doi:http://dx.doi.org/10.1105/tpc.019901
  6. ↑ Ohgishi M, Saji K, Okada K, Sakai T. Functional analysis of each blue light receptor, cry1, cry2, phot1, and phot2, by using combinatorial multiple mutants in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2223-8. PMID:14982991
  7. ↑ Lariguet P, Schepens I, Hodgson D, Pedmale UV, Trevisan M, Kami C, de Carbonnel M, Alonso JM, Ecker JR, Liscum E, Fankhauser C. PHYTOCHROME KINASE SUBSTRATE 1 is a phototropin 1 binding protein required for phototropism. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10134-9. Epub 2006 Jun 15. PMID:16777956 doi:http://dx.doi.org/10.1073/pnas.0603799103
  8. ↑ Sullivan S, Thomson CE, Lamont DJ, Jones MA, Christie JM. In vivo phosphorylation site mapping and functional characterization of Arabidopsis phototropin 1. Mol Plant. 2008 Jan;1(1):178-94. doi: 10.1093/mp/ssm017. Epub 2007 Dec 4. PMID:20031924 doi:http://dx.doi.org/10.1093/mp/ssm017

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