3loj

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[[Image:3loj.png|left|200px]]
 
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{{STRUCTURE_3loj| PDB=3loj | SCENE= }}
{{STRUCTURE_3loj| PDB=3loj | SCENE= }}
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===Structure of Mycobacterium tuberculosis dUTPase H145A mutant===
===Structure of Mycobacterium tuberculosis dUTPase H145A mutant===
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{{ABSTRACT_PUBMED_20601405}}
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{{ABSTRACT_PUBMED_20601405}}
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==Function==
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[[http://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
==About this Structure==
==About this Structure==
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[[3loj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOJ OCA].
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[[3loj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOJ OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020601405</ref><references group="xtra"/>
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<ref group="xtra">PMID:020601405</ref><references group="xtra"/><references/>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: DUTP diphosphatase]]
[[Category: DUTP diphosphatase]]
[[Category: Harmat, V.]]
[[Category: Harmat, V.]]

Revision as of 04:31, 13 February 2014

Template:STRUCTURE 3loj

Contents

Structure of Mycobacterium tuberculosis dUTPase H145A mutant

Template:ABSTRACT PUBMED 20601405

Function

[DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]

About this Structure

3loj is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.

See Also

Reference

  • Pecsi I, Leveles I, Harmat V, Vertessy BG, Toth J. Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res. 2010 Jul 2. PMID:20601405 doi:10.1093/nar/gkq584

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