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4c4w

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4c4w| PDB=4c4w | SCENE= }}
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===Structure of a rare, non-standard sequence k-turn bound by L7Ae protein===
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{{ABSTRACT_PUBMED_24482444}}
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The entry 4c4w is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> [[http://www.uniprot.org/uniprot/RL7A_ARCFU RL7A_ARCFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA and box C/D sRNAs.<ref>PMID:12560482</ref>
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Authors: Huang, L., Lilley, D.M.J.
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==About this Structure==
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[[4c4w]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4W OCA].
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Description: Structure of a rare, non-standard sequence k-turn bound by L7Ae protein
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==Reference==
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<ref group="xtra">PMID:024482444</ref><references group="xtra"/><references/>
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[[Category: Huang, L.]]
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[[Category: Lilley, D M.J.]]
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[[Category: Kink turn]]
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[[Category: Rna binding protein]]
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[[Category: Rna binding protein-rna complex]]

Revision as of 05:00, 13 February 2014

Template:STRUCTURE 4c4w

Contents

Structure of a rare, non-standard sequence k-turn bound by L7Ae protein

Template:ABSTRACT PUBMED 24482444

Function

[SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1] [RL7A_ARCFU] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA and box C/D sRNAs.[2]

About this Structure

4c4w is a 8 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648
  2. ↑ Rozhdestvensky TS, Tang TH, Tchirkova IV, Brosius J, Bachellerie JP, Huttenhofer A. Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea. Nucleic Acids Res. 2003 Feb 1;31(3):869-77. PMID:12560482

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