4kcs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4kcs| PDB=4kcs | SCENE= }}
 +
===Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide===
 +
{{ABSTRACT_PUBMED_24447275}}
-
The entry 4kcs is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
-
Authors: Chreifi, G., Li, H., Poulos, T.L.
+
==About this Structure==
 +
[[4kcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCS OCA].
-
Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide
+
==Reference==
 +
<ref group="xtra">PMID:024447275</ref><references group="xtra"/><references/>
 +
[[Category: Chreifi, G.]]
 +
[[Category: Li, H.]]
 +
[[Category: Poulos, T L.]]
 +
[[Category: Nitric oxide synthase]]
 +
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 05:03, 13 February 2014

Template:STRUCTURE 4kcs

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide

Template:ABSTRACT PUBMED 24447275

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4kcs is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Huang H, Li H, Yang S, Chreifi G, Martasek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J Med Chem. 2014 Jan 30. PMID:24447275 doi:http://dx.doi.org/10.1021/jm401252e

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kcs"
Personal tools