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4kcr

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4kcr| PDB=4kcr | SCENE= }}
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===Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide===
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{{ABSTRACT_PUBMED_24447275}}
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The entry 4kcr is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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Authors: Li, H., Poulos, T.L.
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==About this Structure==
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[[4kcr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCR OCA].
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Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide
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==Reference==
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<ref group="xtra">PMID:024447275</ref><references group="xtra"/><references/>
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[[Category: Li, H.]]
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[[Category: Poulos, T L.]]
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[[Category: Nitric oxide synthase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 05:09, 13 February 2014

Template:STRUCTURE 4kcr

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide

Template:ABSTRACT PUBMED 24447275

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4kcr is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Huang H, Li H, Yang S, Chreifi G, Martasek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J Med Chem. 2014 Jan 30. PMID:24447275 doi:http://dx.doi.org/10.1021/jm401252e

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OCA

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