4cew

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'''Unreleased structure'''
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{{STRUCTURE_4cew| PDB=4cew | SCENE= }}
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===Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD===
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{{ABSTRACT_PUBMED_22388738}}
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The entry 4cew is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/B2ZUN0_9ENTO B2ZUN0_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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Authors: De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
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==About this Structure==
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[[4cew]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CEW OCA].
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Description: Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD
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==Reference==
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<ref group="xtra">PMID:022388738</ref><references group="xtra"/><references/>
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[[Category: Colibus, L De.]]
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[[Category: Fry, E E.]]
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[[Category: Grimes, J.]]
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[[Category: Hu, Z.]]
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[[Category: Kelly, J.]]
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[[Category: Li, X.]]
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[[Category: Peng, W.]]
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[[Category: Puerstinger, G.]]
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[[Category: Rao, Z.]]
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[[Category: Ren, J.]]
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[[Category: Rowlands, D.]]
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[[Category: Spyrou, J A.B.]]
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[[Category: Stonehouse, N.]]
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[[Category: Stuart, D I.]]
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[[Category: Walter, T S.]]
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[[Category: Wang, J.]]
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[[Category: Wang, X.]]
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[[Category: Enterovirus uncoating]]
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[[Category: Hand-foot-and-mouth disease]]
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[[Category: Inhibitor]]
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[[Category: Virus]]

Revision as of 05:09, 13 February 2014

Template:STRUCTURE 4cew

Contents

Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD

Template:ABSTRACT PUBMED 22388738

Function

[B2ZUN0_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

4cew is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, Li X, Yin W, Shen X, Porta C, Walter TS, Evans G, Axford D, Owen R, Rowlands DJ, Wang J, Stuart DI, Fry EE, Rao Z. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2255. PMID:22388738 doi:10.1038/nsmb.2255

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OCA

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