CD3

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<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD2 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry [[1sy6]])' scene=''>
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<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry [[1sy6]])' scene=''>
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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'''CD2 ε chain'''
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'''CD3 ε chain'''
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[[1a81]] – hCD2 ITAM + Syk kinase – human <BR />
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[[1a81]] – hCD3 ITAM + Syk kinase – human <BR />
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[[2k4f]] – mCD2 ITAM – mouse - NMR <BR />
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[[2jxb]] – hCD3 domain SH3-1<br />
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[[3r08]] – mCD2 extracellular domain + antibody<BR />
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[[2k4f]] – mCD3 ITAM – mouse - NMR <BR />
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[[3r08]] – mCD3 extracellular domain + antibody<BR />
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'''CD2 εγ dimer'''
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'''CD3 εγ dimer'''
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[[1jbj]] – hCD2 extracellular domain - NMR<BR />
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[[1jbj]] – hCD3 extracellular domain - NMR<BR />
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[[1sy6]] – hCD2 extracellular domain + antibody<BR />
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[[1sy6]] – hCD3 extracellular domain + antibody<BR />
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'''CD2 εδ dimer'''
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'''CD3 εδ dimer'''
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[[1xiw]] – hCD2 extracellular domain + antibody<BR />
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[[1xiw]] – hCD3 extracellular domain + antibody<BR />
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[[1xmw]] – mCD2 extracellular domain ε/sCD2 extracellular domain δ – sheep<BR />
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[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR />
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'''CD2 ζ chain'''
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'''CD3 ζ chain'''
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[[1ygr]], [[2oq1]] – hCD2 ITAM + CD45 protein tyrosine phosphatase <BR />
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[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR />
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[[3ik5]], [[3ioz]] – hCD2 ITAM + NEF<BR />
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[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR />
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[[2hac]] – hCD2 transmembrane domain - NMR<BR />
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[[2hac]] – hCD3 transmembrane domain - NMR<BR />
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[[Category: Topic Page]]

Revision as of 09:38, 18 February 2014

Structure of human CD3 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry 1sy6)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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