Cephalosporin acylase
From Proteopedia
(Difference between revisions)
| Line 11: | Line 11: | ||
[[1gk0]], [[1gk1]], [[1ghd]] - PsCSA – ''Pseudomonas''<br /> | [[1gk0]], [[1gk1]], [[1ghd]] - PsCSA – ''Pseudomonas''<br /> | ||
[[2ae3]], [[2ae5]] - PsCSA α + β (mutant) subunits<br /> | [[2ae3]], [[2ae5]] - PsCSA α + β (mutant) subunits<br /> | ||
| - | [[2ae4]] - PsCSA α (mutant) + β subunits<br /> | + | [[2ae4]], [[4e55]], [[4e56]], [[4e57]] - PsCSA α (mutant) + β subunits<br /> |
[[1keh]] - BdCSA precursor (mutant) | [[1keh]] - BdCSA precursor (mutant) | ||
Revision as of 08:08, 19 February 2014
Template:STRUCTURE 1jvz
Cephalosporin acylase (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA). CSA contains 2 non-identical subunits. CSA is used commercially for production of semi-synthetic cephalosporin antibiotics. The active site pocket of CSA is similar to that of penicillin acylase. CSA precursor is cleaved at 2 sites forming the active heterodimer.
3D structures of cephalosporin acylase
Updated on 19-February-2014
2nlz - CSA – Bacillus halodurans
1fm2 - BdCSA – Brevundimonas diminuta
1gk0, 1gk1, 1ghd - PsCSA – Pseudomonas
2ae3, 2ae5 - PsCSA α + β (mutant) subunits
2ae4, 4e55, 4e56, 4e57 - PsCSA α (mutant) + β subunits
1keh - BdCSA precursor (mutant)
