3k1d
From Proteopedia
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{{STRUCTURE_3k1d| PDB=3k1d | SCENE= }} | {{STRUCTURE_3k1d| PDB=3k1d | SCENE= }} | ||
===Crystal structure of glycogen branching enzyme synonym: 1,4-alpha-D-glucan:1,4-alpha-D-GLUCAN 6-glucosyl-transferase from mycobacterium tuberculosis H37RV=== | ===Crystal structure of glycogen branching enzyme synonym: 1,4-alpha-D-glucan:1,4-alpha-D-GLUCAN 6-glucosyl-transferase from mycobacterium tuberculosis H37RV=== | ||
| - | {{ | + | {{ABSTRACT_PUBMED_20444687}} |
==Function== | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/GLGB_MYCTU GLGB_MYCTU]] Essential enzyme that catalyzes the formation of the alpha-1,6-glucosidic linkages in glucan chains by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan.<ref>PMID:17005418</ref><ref>PMID:18808383</ref> | + | [[http://www.uniprot.org/uniprot/GLGB_MYCTU GLGB_MYCTU]] Essential enzyme that catalyzes the formation of the alpha-1,6-glucosidic linkages in glucan chains by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan.<ref>PMID:17005418</ref> <ref>PMID:18808383</ref> |
==About this Structure== | ==About this Structure== | ||
| - | [[3k1d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3k1d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_sp._h37rv Mycobacterium sp. h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K1D OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020444687</ref><references group="xtra"/><references/> |
[[Category: 1,4-alpha-glucan branching enzyme]] | [[Category: 1,4-alpha-glucan branching enzyme]] | ||
| - | [[Category: Mycobacterium | + | [[Category: Mycobacterium sp. h37rv]] |
[[Category: Kumar, S.]] | [[Category: Kumar, S.]] | ||
[[Category: Pal, K.]] | [[Category: Pal, K.]] | ||
Revision as of 14:09, 19 February 2014
Contents |
Crystal structure of glycogen branching enzyme synonym: 1,4-alpha-D-glucan:1,4-alpha-D-GLUCAN 6-glucosyl-transferase from mycobacterium tuberculosis H37RV
Template:ABSTRACT PUBMED 20444687
Function
[GLGB_MYCTU] Essential enzyme that catalyzes the formation of the alpha-1,6-glucosidic linkages in glucan chains by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan.[1] [2]
About this Structure
3k1d is a 1 chain structure with sequence from Mycobacterium sp. h37rv. Full crystallographic information is available from OCA.
Reference
- Pal K, Kumar S, Sharma S, Garg SK, Alam MS, Xu HE, Agrawal P, Swaminathan K. Crystal structure of full-length Mycobacterium tuberculosis H37Rv glycogen branching enzyme: insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity. J Biol Chem. 2010 Jul 2;285(27):20897-903. doi: 10.1074/jbc.M110.121707. Epub, 2010 May 5. PMID:20444687 doi:http://dx.doi.org/10.1074/jbc.M110.121707
- ↑ Garg SK, Alam MS, Kishan KV, Agrawal P. Expression and characterization of alpha-(1,4)-glucan branching enzyme Rv1326c of Mycobacterium tuberculosis H37Rv. Protein Expr Purif. 2007 Feb;51(2):198-208. Epub 2006 Aug 22. PMID:17005418 doi:10.1016/j.pep.2006.08.005
- ↑ Sambou T, Dinadayala P, Stadthagen G, Barilone N, Bordat Y, Constant P, Levillain F, Neyrolles O, Gicquel B, Lemassu A, Daffe M, Jackson M. Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice. Mol Microbiol. 2008 Nov;70(3):762-74. doi: 10.1111/j.1365-2958.2008.06445.x. Epub, 2008 Sep 18. PMID:18808383 doi:10.1111/j.1365-2958.2008.06445.x
