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4leg
From Proteopedia
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{{STRUCTURE_4leg| PDB=4leg | SCENE= }} | {{STRUCTURE_4leg| PDB=4leg | SCENE= }} | ||
===Human cathepsin K mutant C25S in complex with an allosteric modifier=== | ===Human cathepsin K mutant C25S in complex with an allosteric modifier=== | ||
| + | {{ABSTRACT_PUBMED_24518821}} | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
[[4leg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEG OCA]. | [[4leg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEG OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Cathepsin|Cathepsin]] | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024518821</ref><references group="xtra"/><references/> |
[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
[[Category: Baici, A.]] | [[Category: Baici, A.]] | ||
Revision as of 15:13, 19 February 2014
Contents |
Human cathepsin K mutant C25S in complex with an allosteric modifier
Template:ABSTRACT PUBMED 24518821
Disease
[CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.[1] [2] [3] [4]
Function
[CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
About this Structure
4leg is a 1 chain structure. Full crystallographic information is available from OCA.
See Also
Reference
- Novinec M, Korenc M, Caflisch A, Ranganathan R, Lenarcic B, Baici A. A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods. Nat Commun. 2014 Feb 11;5:3287. doi: 10.1038/ncomms4287. PMID:24518821 doi:http://dx.doi.org/10.1038/ncomms4287
- ↑ Gelb BD, Shi GP, Chapman HA, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science. 1996 Aug 30;273(5279):1236-8. PMID:8703060
- ↑ Gelb BD, Willner JP, Dunn TM, Kardon NB, Verloes A, Poncin J, Desnick RJ. Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis. Am J Hum Genet. 1998 Apr;62(4):848-54. PMID:9529353 doi:S0002-9297(07)60977-X
- ↑ Ho N, Punturieri A, Wilkin D, Szabo J, Johnson M, Whaley J, Davis J, Clark A, Weiss S, Francomano C. Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein. J Bone Miner Res. 1999 Oct;14(10):1649-53. PMID:10491211
- ↑ Haagerup A, Hertz JM, Christensen MF, Binderup H, Kruse TA. Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population. Eur J Hum Genet. 2000 Jun;8(6):431-6. PMID:10878663 doi:10.1038/sj.ejhg.5200481
