4jje
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | [[4jje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4jje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJE OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[Caspase|Caspase]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/> | ||
[[Category: Caspase-3]] | [[Category: Caspase-3]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Gonzalez-Paez, G E.]] | [[Category: Gonzalez-Paez, G E.]] | ||
[[Category: Vickers, C J.]] | [[Category: Vickers, C J.]] | ||
Revision as of 15:30, 19 February 2014
Contents |
Caspase-3 specific unnatural amino acid peptides
Template:ABSTRACT PUBMED 23614665
Function
[CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.[1] [2]
About this Structure
4jje is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Vickers CJ, Gonzalez-Paez GE, Wolan DW. Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. ACS Chem Biol. 2013 May 3. PMID:23614665 doi:10.1021/cb400209w
- ↑ Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995 Jul 6;376(6535):37-43. PMID:7596430 doi:http://dx.doi.org/10.1038/376037a0
- ↑ Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem. 2011 Apr 22;286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub, 2011 Feb 28. PMID:21357690 doi:10.1074/jbc.M110.195461
