4c0h

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-	'''Unreleased structure'''	+	{{STRUCTURE_4c0h| PDB=4c0h | SCENE= }}
		+	===Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in Gly135Arg point mutant===
		+	{{ABSTRACT_PUBMED_24508575}}
-	The entry 4c0h is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CLP1_YEAST CLP1_YEAST]] Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex.<ref>PMID:11344258</ref>
-	Authors: Dupin, A.F., Fribourg, S.	+	==About this Structure==
		+	[[4c0h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0H OCA].
-	Description: Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in Gly135Arg point mutant	+	==Reference==
		+	<ref group="xtra">PMID:024508575</ref><references group="xtra"/><references/>
		+	[[Category: Dupin, A F.]]
		+	[[Category: Fribourg, S.]]
		+	[[Category: 3' end mrna processing]]
		+	[[Category: Mutant]]
		+	[[Category: Transcription]]

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Revision as of 17:17, 19 February 2014

Template:STRUCTURE 4c0h

Contents 1 Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in Gly135Arg point mutant 2 Function 3 About this Structure 4 Reference

Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in Gly135Arg point mutant

Template:ABSTRACT PUBMED 24508575

Function

[CLP1_YEAST] Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex.^[1]

About this Structure

4c0h is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

• Dupin AF, Fribourg S. Structural basis for ATP loss by Clp1p in a G135R mutant protein. Biochimie. 2014 Feb 5. pii: S0300-9084(14)00035-2. doi:, 10.1016/j.biochi.2014.01.017. PMID:24508575 doi:http://dx.doi.org/10.1016/j.biochi.2014.01.017

1. ↑ Gross S, Moore C. Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6080-5. Epub 2001 May 8. PMID:11344258 doi:http://dx.doi.org/10.1073/pnas.101046598