4n9e

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'''Unreleased structure'''
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{{STRUCTURE_4n9e| PDB=4n9e | SCENE= }}
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===Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
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{{ABSTRACT_PUBMED_24433859}}
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The entry 4n9e is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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Authors: Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y, Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
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==About this Structure==
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[[4n9e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9E OCA].
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Description: Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
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==Reference==
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<ref group="xtra">PMID:024433859</ref><references group="xtra"/><references/>
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Baumeister, T.]]
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[[Category: Bravo, B.]]
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[[Category: Brien, T O.]]
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[[Category: Dragovich, P S.]]
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[[Category: Giannetti, A M.]]
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[[Category: Ho, Y.]]
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[[Category: Hua, R.]]
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[[Category: Li, G.]]
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[[Category: Liang, X.]]
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[[Category: Oh, A.]]
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[[Category: Skelton, N J.]]
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[[Category: Wang, C.]]
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[[Category: Wang, W.]]
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[[Category: Wang, Y.]]
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[[Category: Xiao, Y.]]
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[[Category: Yuen, P.]]
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[[Category: Zak, M.]]
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[[Category: Zhao, G.]]
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[[Category: Zhao, Q.]]
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[[Category: Zheng, X.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 17:24, 19 February 2014

Template:STRUCTURE 4n9e

Contents

Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Template:ABSTRACT PUBMED 24433859

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this Structure

4n9e is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Dragovich PS, Zhao G, Baumeister T, Bravo B, Giannetti AM, Ho YC, Hua R, Li G, Liang X, Ma X, O'Brien T, Oh A, Skelton NJ, Wang C, Wang W, Wang Y, Xiao Y, Yuen PW, Zak M, Zhao Q, Zheng X. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2014 Feb 1;24(3):954-62. doi: 10.1016/j.bmcl.2013.12.062., Epub 2013 Dec 21. PMID:24433859 doi:http://dx.doi.org/10.1016/j.bmcl.2013.12.062

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OCA

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