3il8
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model | + | The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding. |
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Appella, E.]] | [[Category: Appella, E.]] | ||
| - | [[Category: Baldwin, E | + | [[Category: Baldwin, E T.]] |
| - | [[Category: Charles, R | + | [[Category: Charles, R St.]] |
| - | [[Category: Clore, G | + | [[Category: Clore, G M.]] |
| - | [[Category: Edwards, B | + | [[Category: Edwards, B F.P.]] |
| - | [[Category: Gronenborn, A | + | [[Category: Gronenborn, A M.]] |
[[Category: Matsushima, K.]] | [[Category: Matsushima, K.]] | ||
| - | [[Category: Weber, I | + | [[Category: Weber, I T.]] |
[[Category: Wlodawer, A.]] | [[Category: Wlodawer, A.]] | ||
| - | [[Category: Xuan, J | + | [[Category: Xuan, J C.]] |
[[Category: Yamada, M.]] | [[Category: Yamada, M.]] | ||
[[Category: preliminary]] | [[Category: preliminary]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:09:55 2008'' |
Revision as of 17:09, 21 February 2008
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CRYSTAL STRUCTURE OF INTERLEUKIN 8: SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY
Contents |
Overview
The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.
Disease
Known disease associated with this structure: AIDS, slow progression to OMIM:[146929]
About this Structure
3IL8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of interleukin 8: symbiosis of NMR and crystallography., Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al., Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6. PMID:1988949
Page seeded by OCA on Thu Feb 21 19:09:55 2008
