4opa

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m (Protected "4opa" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4opa| PDB=4opa | SCENE= }}
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===X-ray structure of H6N6-NS1 delta(80-84) mutant===
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{{ABSTRACT_PUBMED_24478439}}
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The entry 4opa is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/Q20NS3_9INFA Q20NS3_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism (By similarity).[SAAS:SAAS000256_004_252803] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells (By similarity).[SAAS:SAAS000256_004_198562]
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Authors: Carrillo, B.
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==About this Structure==
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[[4opa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPA OCA].
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Description: X-ray structure of H6N6-NS1 delta(80-84) mutant
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==Reference==
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<ref group="xtra">PMID:024478439</ref><references group="xtra"/><references/>
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[[Category: Carrillo, B.]]
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[[Category: Alpha-helix beta-crescent fold]]
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[[Category: Interferon antagonist]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Sumoylation]]
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[[Category: Viral protein]]

Revision as of 17:26, 19 February 2014

Template:STRUCTURE 4opa

Contents

X-ray structure of H6N6-NS1 delta(80-84) mutant

Template:ABSTRACT PUBMED 24478439

Function

[Q20NS3_9INFA] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism (By similarity).[SAAS:SAAS000256_004_252803] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells (By similarity).[SAAS:SAAS000256_004_198562]

About this Structure

4opa is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

Proteopedia Page Contributors and Editors (what is this?)

OCA

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