4lek

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'''Unreleased structure'''
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{{STRUCTURE_4lek| PDB=4lek | SCENE= }}
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===Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines===
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{{ABSTRACT_PUBMED_24428639}}
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The entry 4lek is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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Authors: Hilgers, M.T.
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==About this Structure==
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[[4lek]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEK OCA].
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Description: Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines
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==Reference==
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<ref group="xtra">PMID:024428639</ref><references group="xtra"/><references/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Hilgers, M T.]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 17:27, 19 February 2014

Template:STRUCTURE 4lek

Contents

Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines

Template:ABSTRACT PUBMED 24428639

Function

[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4lek is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Lam T, Hilgers MT, Cunningham ML, Kwan BP, Nelson KJ, Brown-Driver V, Ong V, Trzoss M, Hough G, Shaw KJ, Finn J. Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines. J Med Chem. 2014 Feb 13;57(3):651-68. doi: 10.1021/jm401204g. Epub 2014 Jan 16. PMID:24428639 doi:http://dx.doi.org/10.1021/jm401204g

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