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4cap

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4cap| PDB=4cap | SCENE= }}
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===Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine===
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{{ABSTRACT_PUBMED_24472039}}
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The entry 4cap is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
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Authors: Li, H., Poulos, T.L.
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==About this Structure==
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[[4cap]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAP OCA].
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Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2-amine
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==Reference==
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<ref group="xtra">PMID:024472039</ref><references group="xtra"/><references/>
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[[Category: Li, H.]]
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[[Category: Poulos, T L.]]
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[[Category: Inhibitor complex]]
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[[Category: Nitric oxide synthase]]
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[[Category: Oxidoreductase]]

Revision as of 17:27, 19 February 2014

Template:STRUCTURE 4cap

Contents

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine

Template:ABSTRACT PUBMED 24472039

Function

[NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

About this Structure

4cap is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Cinelli MA, Li H, Chreifi G, Martasek P, Roman LJ, Poulos TL, Silverman RB. Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition. J Med Chem. 2014 Feb 10. PMID:24472039 doi:http://dx.doi.org/10.1021/jm401838x

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OCA

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