3kin
From Proteopedia
(New page: 200px<br /> <applet load="3kin" size="450" color="white" frame="true" align="right" spinBox="true" caption="3kin, resolution 3.1Å" /> '''KINESIN (DIMERIC) FR...) |
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| - | [[Image:3kin.gif|left|200px]]<br /> | + | [[Image:3kin.gif|left|200px]]<br /><applet load="3kin" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="3kin" size=" | + | |
caption="3kin, resolution 3.1Å" /> | caption="3kin, resolution 3.1Å" /> | ||
'''KINESIN (DIMERIC) FROM RATTUS NORVEGICUS'''<br /> | '''KINESIN (DIMERIC) FROM RATTUS NORVEGICUS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The dimeric form of the kinesin motor and neck domain from rat brain with | + | The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helical interaction of their necks. They are broadly similar to one another; differences are most apparent in the head-neck junction and in a moderate reorientation of the neck helices in order to adopt to the coiled-coil conformation. The heads show a rotational symmetry (approximately 120 degrees) about an axis close to that of the coiled-coil. This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules. |
==About this Structure== | ==About this Structure== | ||
| - | 3KIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ADP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 3KIN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http:// | + | 3KIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 3KIN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Kozielski, F.]] | [[Category: Kozielski, F.]] | ||
[[Category: Mandelkow, E.]] | [[Category: Mandelkow, E.]] | ||
| - | [[Category: Mandelkow, E | + | [[Category: Mandelkow, E M.]] |
[[Category: Marx, A.]] | [[Category: Marx, A.]] | ||
[[Category: Sack, S.]] | [[Category: Sack, S.]] | ||
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[[Category: motor protein]] | [[Category: motor protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:09:57 2008'' |
Revision as of 17:10, 21 February 2008
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KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
Overview
The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helical interaction of their necks. They are broadly similar to one another; differences are most apparent in the head-neck junction and in a moderate reorientation of the neck helices in order to adopt to the coiled-coil conformation. The heads show a rotational symmetry (approximately 120 degrees) about an axis close to that of the coiled-coil. This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules.
About this Structure
3KIN is a Protein complex structure of sequences from Rattus norvegicus with as ligand. The following page contains interesting information on the relation of 3KIN with [Kinesin]. Full crystallographic information is available from OCA.
Reference
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility., Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E, Cell. 1997 Dec 26;91(7):985-94. PMID:9428521
Page seeded by OCA on Thu Feb 21 19:09:57 2008
